Endocrine Abstracts

Severe thyroid dysfunction may lead to menstrual disorders and subfertility via direct and indirect interactions with the hypothalamo–pituitary–ovarian axis and the reproductive organs. However, the exact prevalence of subfertility in women with thyroid disorders remains unknown. Fertility problems may persist after restoring normal thyroid function, and then surgery and/or an assisted reproductive technology (ART) may be necessary to obtain a pregnancy. The initial ...

To adapt the working of the thyroid to the changes occurring during pregnancy, an adequate availability of iodine and the integrity of the thyroid gland are needed. With regard to thyroid function assessment during pregnancy, is it important to be aware of the differences in accuracy of the different FT4 assays. Thyroid autoimmunity (TAI) is the most common cause of hypothyroidism before and during pregnancy and many women with TAI and a normal thyroid function in e...

Objective: Pregnant women with autoimmune (subclinical) hypothyroidism have an increased risk of developing gestational diabetes mellitus (GDM). However, this association remains controversial in euthyroid women with thyroid autoimmunity (TAI). Therefore, the aim of the study was to determine the association between TAI and GDM in euthyroid women in a logistic regression analysis with adjustments for baseline/demographic parameters.Methods: Cross-section...

Context/Objective: Evidence on the impact of thyroid hormone treatment (LT4) on pregnancy outcomes in women with subclinical hypothyroidism (SCH) without TPOAb remains scarce. We assessed this relationship in a single centre in a real-world setting.Design, Setting, Participants: Cross-sectional study in 1460 women screened for TSH, free T4 and thyroid peroxidase antibodies (TPOAb) at median 13 (11-17) weeks of gestation, during the period 2013-2014. Excl...

Background: Thyroid autoimmunity (TAI) is the most important cause of hypothyroidism in the general population, and its prevalence is higher in women of subfertile couples.1 Women pregnant after an assisted reproductive technology (ART) with TAI carry a higher risk of a first trimester miscarriage rate compared to women without TAI. Several reasons could be underlying such as thyroid dysfunction, older age, an immune imbalance, and the presence of thyrotropin recept...